Vascular growth and remodeling are continuous processes vital for development and homeostasis.Angiogenesis, the process that generates new vessels from pre-existing vessels, persists throughout development, coordinated with organ growth and repair.It remains unclear how the EC pool is replenished during homeostasis, i.e., whether it is from the contribution of mature EC proliferation, or the result of vascular stem/progenitor cell activities.This represents a novel origin of pericytes in adult angiogenesis, reshaping our understanding of blood vessel development and homeostatic process.Our study may also provide a more precise therapeutic target to inhibit pathological angiogenesis and tumor growth.
It is widely recognized that pericytes have mesenchymal or hematopoietic origin and that they are recruited to endothelial tubes.
ECs are the fundamental building blocks of the vascular architecture.
The perivascular pericytes in adult tissues are thought to arise from the recruitment and differentiation of mesenchymal progenitors during early development.
In this study, we identified Protein C receptor-expressing (Procr VESCs are bipotent, giving rise to de novo formation of endothelial cells and pericytes.
The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Correspondence: Yi Arial Zeng, Tel: +-1433; Fax: +-1225 Email: [email protected] Received 29 April 2016; Revised ; Accepted Advance online publication 1 July 2016Vascular growth and remodeling are dependent on the generation of new endothelial cells from stem cells and the involvement of perivascular cells to maintain vessel integrity and function.
The existence and cellular identity of vascular endothelial stem cells (VESCs) remain unclear.