Clinical trials are needed to define whether hyporesponders to clopidogrel are at increased risk for thrombotic events and whether hyper-responders are at increased risk for bleeding.When hyporesponsiveness and hyper-responsiveness to clopidogrel were considered to be two standard deviations less than and greater than the mean, respectively, the prevalence of hyporesponsiveness and hyper-responsiveness in these patients was 4.2% and 4.8%, respectively.Staying at the city's Hyatt Regency, a guest claims four girls in bikinis were at the hotel's pool when the 19-year-old pop star looked over at one of them and reportedly asked: 'What are you, Hawaiian or something? Justin added insult to injury by then reportedly saying: 'You should go on (weight loss reality show) The Biggest Loser!' Another guest from the hotel insisted that after this outburst there was silence by the pool, according to The Sun newspaper and blogger Perez Hilton.Pretreatment platelet activity and clinical characteristics were not associated with responsiveness to clopidogrel.
Like the studies of aspirin that preceded them, these studies are relatively small and use different platelet assessments and definitions for determining responsiveness.Recently, a number of reports, using various definitions, have dichotomized patients who are treated with clopidogrel into a minority of “non-responders” and a majority of “responders.” Such classifications imply that treatment leads to an all-or-none response, with potentially important clinical implications.We conducted secondary post-hoc analyses of a dataset consisting of volunteers (n = 94) and patients after coronary stenting (n = 405), with heart failure (n = 25), and after stroke (n = 20).On Monday, Justin put in a call to his old friend Ryan Seacrest on his radio show for a chat.The clinical implications of this variability are unknown but potentially are important.
We sought to describe the responses of patients to clopidogrel using ex vivo measures of platelet aggregation and activation in a large, heterogeneous population.