One Tree Hill debuted in 2003 and quickly went on to secure a cult following.
Over the course of its nine seasons it picked up numerous Teen Choice Awards and nominations.
Hilarie played main character Peyton Sawyer on the series before leaving after series six.
Unfortunately the blonde didn't pick up and ended up missing out on all the fun.
However others included Antwon Tanner, who played Skills, and Daphne Zuniga, who played Brooke's mum Victoria.
The image was shared on Instagram with Sophia's 1.8 followers.
Perhaps the biggest names present were Bethany Joy Lenz, who played musician Haley James Scott, and Paul Johansson, who played villain Dan Scott.
It's finally happened - the cast of One Tree Hill have reunited.
Sophia Bush, who played Brooke Davis on the teen drama, managed to gather a number of her former co-stars together for a picture over the weekend.
The series ended in 2012 after viewership dropped to an average of 1.8 million in the US.
star answered a caller -- and then some -- on whether or not she keeps in touch with her ex. PHOTOS: Ugly celebrity breakups "That's such an interesting question," the 31-year-old laughed.
"But my mother once said to me that if you don't have anything nice to say, not to say anything at all." Bush and Murray, 32, married in April 2005 after meeting on set of the TV series in 2003.