Sometimes, however, a plasma cell may become malignant and begins to divide uncontrollably, forming tumours in the bone marrow, eroding the surrounding bone and producing producing soft spots and holes known as lytic lesions.Myeloma can develop wherever there is bone marrow, including the pelvis, spine and ribcage.Are you really doing everything you can to get the most out of that release?Are you working with the tools that will significantly bump up the number of reads and click-throughs for that release? John Jantsch, founder of Duct Tape Marketing, is known as the “World´s Most Practical Small Business Expert” for consistently delivering real-world, proven small business marketing ideas and strategies.Myeloma is a cancer that develops in cells of the bone marrow called plasma cells.
They share space in the bone marrow with maturing red blood cells (RBCs), platelets, and several types of white blood cells (WBCs).
Within a plasma cell, two heavy chains of one type and two light chains of one type become attached to form one intact immunoglobulin.
Each type of immunoglobulin is composed of four protein chains - two identical heavy (long) protein chains and two identical light (shorter) protein chains.
The light chains consist of one of two different types called kappa and lambda.
The abnormal antibody does not work properly and is not able to fight infections while the proliferation of malignant cells can affect the production of normal antibodies (immunosuppression), causing susceptibility to infection.
Normally, the body makes five different types of immunoglobulins - Ig G, Ig A, Ig M, Ig E and Ig D - that have slightly different immune system functions.