Tamoxifen resistance in breast cancer elucidating mechanisms

Tamoxifen resistance in breast cancer elucidating mechanisms

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Rationally chosen combination regimens are now under clinical investigation.Recent data underline the functional importance of the tumour-associated stroma, with several candidate molecular targets now emerging.Extensive preclinical experimentation has conceptually changed the way we perceive breast cancer, with the wide spectrum of genomic alterations governing its malignant progression now being recognized.Functional genomics has helped us identify important genetic defects that can be pharmaceutically targeted in the setting of metastatic disease.This cookie stores just a session ID; no other information is captured.

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